Elon University Home

Kathy Matera

Associate Professor of Chemistry
McMichael Science Building 303
2625 Campus Box
Elon, NC 27244
kmatera@elon.edu (336) 278-6226

Education

1988    Ph.D., Organic Chemistry, University of California at Davis. 

1984    Bachelor of Arts (Honors), Chemistry with Biology minor, Pitzer College (Claremont Colleges).

Employment History

2007-present   Associate Professor, Department of Chemistry, Elon University

2002–2007      Associate Professor and Chair, Department of Chemistry, Baldwin-Wallace College

2003               Visiting Scientist, Wellcome Trust Biocentre, Department of Biochemistry, University of Dundee, Scotland.  

1997–2002      Assistant Professor, Department of Chemistry, Baldwin-Wallace College, Berea OH.

1995–1996      Visiting Assistant Professor, Department of Chemistry, John Carroll University, University Heights, OH.

1994-1995       Postdoctoral Fellow, Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH.

1990-1994       Senior Research Scientist, SymBiotech, Inc., Wallingford, CT.

1988-1990       Research Chemist, Chevron Research and Technology Company, Richmond, CA. 

Courses Taught

(At Elon University)

CHM 111/112  General Chemistry I and II

CHM 212  Organic Chemistry II

CHM 351/353  Biochemistry I and II

CHM 473  Medicinal Chemistry

CHM 495  Biochemistry Seminar

Research

The students working in my research lab are involved with projects typically related to enzymatic mechanisms, peptide aggregations and their relationship to neurological dysfunction, and oxidative stress mechanisms.  Recent projects have included (1) examining enzyme inhibitors for acetylcholinesterase, an integral enzyme in the manifestation of Alzheimer's disease symptoms, (2) amyloid beta and alpha synuclein aggregates, short peptides that when aggregated cause cellular anomalies that can lead to Alzheimer's or Parkinson's disease, and (3) the oxidative mechanism of myeloperoxidase and lactoperoxidase, two enzymes integrally involved with biochemical pathways for immunological defense.

Publications

(Only more recent articles listed; *denotes undergraduate researcher)

Mansfield Matera, K. Isolation, Characterization and Utilization of Horseradish Peroxidase: A Multiweek Undergraduate Biochemistry Laboratory, submitted J. Chem. Ed., June 2013.

*Peckels, C.M., *Alexander, N.S., *Wilson, G.N., Karty, J.M., Mansfield Matera, K.  Trisubstituted phenolic compounds as inhibitors of acetylcholinesterase and amyloid beta aggregate formation.  Current Enzyme Inhibition, 2013, 9, 67-74.

*Clark, A.L., Matera, K.M., Effect of unsaturation in fatty acids on the binding and oxidation by myeloperoxidase: Ramifications for the initiation of atherosclerosis.  Bioorganic and Medicinal Chemistry Letters, 2010, 20, 5643–5648.

*Wilson, G.N., Mickley, G.A., and Matera, K.M. The efficacy of ellagic acid in attenuating neurophysiological and cognitive-behavioral symptoms associated with infusion of amyloid-beta (Aβ) peptide fragments in adult rats. Journal of Research and Creative Studies, 2010, 3, 15-30. Available: http://www.bw.edu/resources/dean/fscs/jrcs/JRCS_Vol_3_Issue_1.pdf

Urbaniak, M.D., Tabudravu, J.N., Msaki, A., Mansfield Matera, K., Jaspars, M., Ferguson, M.A.J.  Identification of Novel Inhibitors of UDP-Glc 4’-Epimerase, a Validated Drug Target for African Sleeping Sickness.  Bioorganic and Medicinal Chemistry Letters, 2006, 16, 5744-5747.

Matsui, T.,  Nakajima, A., Fujii,, H., Mansfield Matera, K., Migita, C., Yoshida, T., Ikeda-Saito, M. O2- and H2O2-Dependent Verdoheme Degradation by Heme Oxygenase:  Reaction Mechanisms and Potential Physiological Roles of the Dual pathway DegradationJ. Biol Chem. 2005, 280, 36833-36840.

Zhang, X., Fujii, H., Mansfield Matera, K., Migita, C.T., Sun, D., Sato, M., Ikeda-Saito, M., Yoshida, T.  Stereoselectivity of each of the three steps of the heme oxygenase reaction: hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin.  Biochemistry, 2003, 42, 7418-7426.

Presentations

(Only presentations from Elon University given;  *denotes undergraduate presenter; university presentations from Spring Undergraduate Research Forum events not listed)

*Fischer, A., Mansfield Matera, K., Investigation into ROS oxidation products of dopamine.  Presented at the American Chemical Society Southeastern Regional Meeting, Raleigh, NC, November 2012, Abstract 876.

*Knaus, K., Mansfield Matera, K., Determination and alteration of the loci of aggregation in amyloid beta and insulin. Presented at the American Chemical Society Southeastern Regional Meeting, Raleigh, NC, November 2012, Abstract 877.

*Helman, A., Mansfield Matera, K., Inhibitory effects of Congo red dye on amyloid beta plaque formation.  Presented at the American Chemical Society Southeastern Regional Meeting, Raleigh, NC, November 2012, Abstract 880.

*Dalgetty, M., Mansfield Matera, K., Analysis of Amyloid-beta Aggregation.  Presented at the American Chemical Society Southeastern Regional Meeting, Raleigh, NC, November 2012, Abstract 1247.

*Frazier, M., Mansfield Matera, K., Investigating the oxidative abilities of amyloid-beta.  Presented at the American Chemical Society Southeastern Regional Meeting, Richmond, VA, October 2011.

*Pratt, A.T., Mansfield Matera K., Effect of Amyloid Beta on Acetylcholinesterase.  Presented at the American Chemical Society Southeastern Regional Meeting, Richmond, VA, October 2011.

*Clark, A., Mansfield Matera, K. Understanding the Role of the Body’s Immune System In Atherosclerosis Through Analysis of TLR4 and Fibrinogen Interactions.  Presented at the National Conference for Undergraduate Research, Ithaca, NY, March 2011.

*Peckels, C., Mansfield Matera, K. Synthesis of Gallic Acid Derivatives:  Implications in the Treatment of Alzeheimer’s Disease.  Presented at the American Chemical Society Southeastern Regional Meeting, New Orleans, LA, December 2010; Abstract 1141.

*Dennin, S. Mansfield Matera, K. Oxidation of high-density lipoproteins. Presented at the American Chemical Society Southeastern Regional Meeting, Puerto Rico, October 2009; Abstract 238.

*Dennin, S., Mansfield Matera, K. Oxidation of high-density lipoproteins:  A contributor to heart disease.  Presented at the American Chemical Society National Meeting, Washington DC, August 2009; Abstract CHED 165.

*Clark, A.L., Mansfield Matera, K. Effect of oxidized lipids on the composition of atherosclerotic plaques.  Presented at the American Chemical Society National Meeting, Washington DC, August 2009; Abstract CHED 155).

*Peckels, C., Mansfield Matera, K. Formation of amyloid-beta plaques and their effect on biomolecules.  Presented at the American Chemical Society National Meeting, Washington DC, August 2009; Abstract CHED 159

Professional Activities

American Chemical Society (ACS):  Biological and Organic Chemistry divisions

Council for Undergraduate Research (CUR)

Iota Sigma Pi:  Honorary Society for Women Chemists

Sigma Xi Fellow

Awards

(Only awards from Elon University listed)

2011   Dr. Gerald L. Francis Outstanding Faculty Member of the Year

2009     A.L. Hook Emerging Scholar in Science and Mathematics