Vickie Moore

Assistant Professor of Chemistry
McMichael Science Building 311
2625 Campus Box
Elon, NC 27244
vmoore3@elon.edu (336) 278-6221

Education

B.S. James Madison Univeristy 1999

Ph.D. Wake Forest University School of Medicine 2004

Postdoctoral Fellowship Dana-Farber Cancer Institute 2004 - 2009
 

Employment History

Problem Based Learning Lead Facilitor (Biochemistry) WFUSM Physician Assistant Program 2003

Adjunct Facutly (Biochemistry/Chemistry) Simmons College 2005 - 2007

Scientist Clean Earth Technologies 2009 - 2010

Assistant Professor Elon University (Biochemistry/Chemistry) 2010 - present
 

Courses Taught


CHM 111, CHM 111L  General Chemistry

CHM 462L Biochemistry I

CHM 463, CHM 463L Advanced Biochemistry

CHM 374 Medicinal and Pharmaceutical Chemistry

CHM 495 Senior Seminar in Biochemistry

Research

Dr. Moore's research focuses on changes to mitochondria during the disease process. She is specifically interested in the BCL-2 family of proteins, which control cell death, and uses biochemical techniques such as portein isolation, cell culture, protein-protein interactions, Western Blotting, and cell viability assays. The current projects in her lab use cell culture models of Type II Diabetes, Prostate Cancer, and Sepsis.
 

Current Projects


 

Grants Awarded

April 2012                    NC Biotech Institutional Development Grant; Aquisition of a flow cytometer for

                                   collaborative and interdisciplinary use at Elon Universy; role- Principle Investigator

September 2012        NSF MRI grant; Aquisition of a multi-mode platereader for research and teaching;  

                                role- Principle Investigator

May 2011                   Faculty Fund for Excellence, Equipment Grant, Elon University; 1 year, role-

                                 Co-Principle Investigator

January 2011               Associate Provost for Faculty Affairs Research Grant, Elon University

                                    1 year,  role- Principle Investigator

January  2007              American Cancer Society Post-doctoral Fellowshi 3 years, role- PI

July 2002                     American Heart Association Pre-doctoral Fellowship 2 years, role- PI

June-August 1998         American Society for Microbiology Undergraduate Research Fellowship, role- PI

June-August 1997         National Science Foundation Summer Undergraduate Research Program, Penn

                                    State University,  role- Fellow


 

Publications

 * denotes undergraduate

Lampl, T*., Davis, T*. and Del Gaizo Moore, V. Mitochondria isolation and functional assays to assess cell state. JoVE. Invited manuscript under review.

Bedard, M.E.*, Giffear, K.A.*, Ponton, L., Sienerth, K., and Del Gaizo Moore, V. Molecular Interactions With Humic Acid Diminish Estrogen's Biological Activity. Biophys Chem. 2014 May;189:1-7.

Yancey D., Nelson, K., Baiz, D., Hassan, S., Flores, A., Pullikuth, A, Karpova, Y., Axanova, L.,  Del Gaizo Moore, V., Sui, G., and Kulik, G. BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells. . PLOS ONE. sAugust 2013, Revisions under review.

Vinsant, S., Mansfield, C.,  Jimenz-Moreno, R.,  Del Gaizo Moore, V., Yoshikawa, M., Prevette, D., Oppenheim, R., and Milligan, Characterization of Early Pathogenesis in Spinal Cord of the SOD1G93A Mouse Model of ALS.  Part I: Introduction and Method.s Brain and Behavior. Brain Behav. 2013 Jul;3(4):431-57.

Vinsant, S., Mansfield, C.,  Jimenz-Moreno, R.,  Del Gaizo Moore, V., Yoshikawa, M., Prevette, D., Oppenheim, R., and Milligan, Characterization of Early Pathogenesis in Spinal Cord of the SOD1G93A Mouse Model of ALS.  Part II: Results and Discussion. Brain and Behavior. Brain Behav. 2013 Jul;3(4):355-50.

Crum, J.A*. and Del Gaizo Moore, V.  The Role of Apoptosis in Sepsis-Induced Kidney Dysfunction. JoSR September 2012, 1(3):1-8.   

     * denotes undergraduate

Del Gaizo Moore, V., and and A. Letai. BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions. Cancer Letters 2013 May 28;332(2):202-5.

Chonghaile, T.N., Sarosiek, K.A., Vo, T-T , Ryan, J.A., Tammareddi A., Del Gaizo Moore, V.,  Deng, J., Anderson, K.,  1, Richardson, R.,  Tai, Y-T, Mitsiades, C., Matulonis1,U.A.,  Drapkin, R., Stone,R.,  Deangelo, D.J., McConkey, D.J., Sallan, S.E., Hirsch, M.S., Carrasco, D.R., and A. Letai. Pretreatment mitochondrial priming regulates clinical response to cytotoxic chemotherapy. Science, 2011 Nov 25;334(6059):1129-33.

Del Gaizo Moore, V. and Letai, A. Rational Design of Therapeutics Targeting the Bcl-2 family; Ares some cancer cells primed for death but waiting for a final push? Adv. Exp. Med. Biol., 2008, 615: 159-75.

Del Gaizo Moore, V., Schlis, K., Armstrong, S.A., and A. Letai. Acute lymphocytic leukemia demonstrate a range of sensitivities to BCL2 antagonist ABT-737. Blood, February 2008, 111(4): 2300-2309.

Del Gaizo Moore, V., Brown, J.R., Certo, M., Love, T.M., Novina, C.D., and A. Letai. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. JCI, January 2007, 117(1): 112-121.

Angdisne, J, Moore, VD, Cline JM, Payne, RM, Ibdah, JA. Mitochondrial trifunctional protein defects: molecular basis and novel therapeutic approaches. Curr Drug Targets Immune Endocr Metabol Disord.2005 Mar;5(1):27-40.

Del Gaizo Moore, V. and R.M. Payne. TAT Fusion Protein Transduction Causes Membrane Inversion. JBC. August 2004: 279(31): 32541-32544.
Del Gaizo V., MacKenzie J.A., and R.M. Payne. Targeting Proteins to Mitochondria Using TAT. Mol Genet Metab. Sept. 2003; 80: 170-180.

Hantgan R.R., Stahle M., Del Gaizo V., Adams M., Lasher T., Jerome W.G., McKenzie M., Lyles D.S. Alpha IIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alpha Iib beta3. Biochim Biophys Acta. July 2001; 1540(1):82-95.

Sakamoto T., Delgaizo V.B., and Donald A. Bryant. Growth on Urea Can Trigger Death and Peroxidation of the Cyanobacterium Synechococcus sp. Strain PCC 7002. Appl. Envir. Microbiol. July 1998; 64: 2361-2366.

 

Book Chapter:

Del Gaizo Moore, V. and Letai, A.. "Apoptosis dysregulation in CLL" in Chronic Lymphocytic Leukemia. Edited by Susan O'Brien & John G. Gribben; Informa Healthcare Publishing, 2008.

Presentations

K. Van Dalfsen* and V. Del Gaizo Moore. ASBMB Annunal Meeting, April 2014, San Diego, CA. Platform presentation  and poster presentation.

J. Crum* and V. Moore. ASBMB Annual Meeting, April 2013, Boston, MA. Poster Presentation

M. Bedard*, J. Crum*, K. Van Dalfsen*, R.E. Wilson* and V. Moore. South Eastern Regional Meeting of the American Chemical Society, November 2012, Raleigh, NC. 4 seperate Oral Presentations

R.E. Wilson* and V. Moore. EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, November 2012, Dublin, Ireland. Poster Presentation

K. Van Dalfsen* and V. Moore. American Society for Cell Biology Anual Meeting, December 2011, Denver CO. Poster Presentaiton:

K. Giffear* and V. Moore. NCICUC, ECU. November 2011, Richmond VA. Oral Presentation:

K. Van Dalfsen* and V. Moore. South Eastern Regional Meeting of the Amercian Chemical Society (SERMACS), October 2011, Richmond VA. Oral Presentation:

K. Giffear* and V. Moore. South Eastern Regional Meeting of the Amercian Chemical Society (SERMACS), October 2011, Richmond VA. Oral Presentation:

R. Wilson* and V. Moore. South Eastern Regional Meeting of the Amercian Chemical Society (SERMACS), October 2011, Richmond VA. PosterPresentation:

J.A. Crum* and V. Moore. South Eastern Regional Meeting of the Amercian Chemical Society (SERMACS), October 2011, Richmond VA. Poster Presentation:

*= undergraduate student; bold indicates presenter

Professional Activities

V. Moore, Undergraduate Senior Biochemistry Exam Committee, Amercian Society for Biochemistry and Molecular Biology, November 2013 - present.

V. Moore, Amercian Society for Biochemistry and Molecular Biology Annual Meeting, April 2014, San Diego, CA. Undergraduate Poster Session judge.

V. Moore, American Society for Cell Biology Annual Meeting, December 2011, Richmond, VA.                                                     Women in Cell Biology Professional Session- Table Leader, Undergraduate Teaching and Research
 

V. Moore, Amercian Society for Biochemistry and Molecular Biology Annual Meeting, March 2011, Washington D.C. Undergraduate Poster Judge

 

Skills



 

Professional Development


 

Awards

April 2014       ASBMB-National Science Foundation Award for recognition of excellence in research at a

                      primarily undergraduate instituion. San Diego, CA

 

April  2014       Facutly Travel Award, Amercian Society of Biochemistry and Molecular Biology, Annual

                       meeting, San Diego, CA.

 

December 2011    Undergraduate Faculty Travel Award, Amercian Society for Cell Biology, Annual

                           meeting, Denver, CO.


Undergraduate Student Research Awards

T. Davis* 2013 Lumen Prize, Elon University; Mentor- V. Moore

T. Lampl* 2013 Lumen Prize, Elon University; Mentor- V. Moore

R.E. Wilson* 2012 Best Undergraduate Oral Presentation South Eastern Regional Meeting of the American Chemical Society

K. Van Dalfsen * 2012Best Undergraduate Group Presentation South Eastern Regional Meeting of the American Chemical Society

K. Van Dalfsen* 2012 Goldwater Award (WA); V. Moore-mentor

V. Moore 2011 Undergraduate Teaching Travel Award, ASCB Annual Meeting, Denver, CO.

K. Van Dalfsen* 2011 Undergraduate Student Travel Award, ASCB Annual Meeting, Denver CO; Mentor- V. Moore

R. Wilson* 2011 -2012 and 2012-2013 Glen Raven Scholarship, Elon Unviveristy; Mentor- V. Moore

K. Van Dalfsen* 2011 Lumen Prize, Elon University; Mentor- V. Moore

* denotes undergraduate research student