Yuko Miyamoto

Associate Professor of Biology
McMichael Science Building 224B
2625 Campus Box
Elon, NC 27244
ymiyamoto@elon.edu (336) 278-6201

Professional Expertise

Immunology & Cell Biology; Cell Signaling

Education

Postdoctoral Fellowship

University of North Carolina at Chapel Hill, Chapel Hill, NC

Department of Pharmacology, Dr. Rudy Juliano

 

Ph.D. Immunology

The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas

Dissertation Title:  “Functional and Physical Associations of b1 Integrins in the Activation of Human T Lymphocytes”

Advisor:  Brad W. McIntyre, Ph.D.

 

Bachelor of Science, Pharmacology

University of California, Santa Barbara

Santa Barbara, California

Employment History

Aug 2010           Associate Professor

-present             Elon University, Department of Biology, Elon, NC 

 

Aug 2005           Assistant Professor

-May 2010          Elon University, Department of Biology, Elon, NC 

 

Summer                        Instructor

2010-current                University of North Carolina at Chapel Hill, Chapel Hill, NC

  • BIO101  “Principles of Biology”, BIO202 "Molecular Biology & Genetics

 

Courses Taught

Introductory Cell Biology (BIO111)
Introductory Cell Biology Lab (BIO113)
Sophomore Seminar (BIO261)
Molecular and Cell Biology (BIO422)
Immunology (BIO373)
Cancer Biology (BIO372)
Global Studies-(GST110)
Biology for Non-majors (BIO101)
Bioethics (HNR139A)

Leadership Positions

2011-current      Chair of Yarbrough Grants Committee, North Carolina Academy of Science

2006-2011          Director of Collegiate Association of North Carolina Academy of Science (CANCAS)

  • Assisted and coordinated CANCAS Fall Workshop location
  • Attended Board of Director and Executive Committee meetings
  • Advised and assisted student officers from undergraduate institutions from North Carolina
  • Composed and sent out monthly CANCAS newsletters to North Carolina Undergraduate institutions

Research

My research interests are in the areas of cell biology, cell signaling, cancer biology, and immunology. The research focus is to study how cells move and communicate. I use small interfering RNA molecules (siRNA) to "knock-out" cytoskeletal proteins in the cell and to determine if the loss of a specific protein affects cell communication.

One of the projects involves how the reduction of specific cytoskeletal proteins affects the cell cycle and potentially contributes to cell death. Another area being explored are how decrease in a specific cytoskeletal protein may affect integrin (adhesion protein) signaling pathway. Another area of investigation is how inhibitors of T cell activation may impact T lymphocyte migration and signaling.

In all the research projects, I work with closely with my research students. They learn a variety of techniques, develop important analytical and trouble-shooting skills, and confidence in their research skills. Students present their work at regional and national conferences. Many of my former research students have successfuly obtained entry level research jobs or have gone on to graduate school (Ex.  MD/PhD program, medical school, masters in nutrition, masters in physiology, masters program in prosthetics, Physicians assistants program, accelerated nursing program, research positions at Research Triangle Park, university research lab positions, pharmaceutical or biotechnology companies).

Current Projects

My research interests are in the areas of cell biology, cell signaling, cancer biology, and immunology. The research focus is to study how cells move and communicate. I use small interfering RNA molecules (siRNA) to "knock-out" cytoskeletal proteins in the cell and to determine if the loss of a specific protein affects cell communication.

One of the projects involves how the reduction of specific cytoskeletal proteins affects the cell cycle and potentially contributes to cell death. Another area being explored are how decrease in a specific cytoskeletal protein may affect integrin (adhesion protein) signaling pathway. Another area of investigation is how inhibitors of T cell activation may impact T lymphocyte migration and signaling.

In all the research projects, I work with closely with my research students. They learn a variety of techniques, develop important analytical and trouble-shooting skills, and confidence in their research skills. Students present their work at regional and national conferences. Many of my former research students have successfuly obtained entry level research jobs or have gone on to graduate school (Ex.  MD/PhD program, medical school, masters in nutrition, masters in physiology, masters program in prosthetics, Physicians assistants program, accelerated nursing program, research positions at Research Triangle Park, university research lab positions, pharmaceutical or biotechnology companies).

Grants Awarded

  • “Identification Key Signaling Proteins Under Inhibitory Conditions in T cells and HEK293AD cells” Faculty Research and Development Grant, Elon University 2013-14, $5,877
  • “Acquisition of Flow Cytometry for Interdisciplinary and Collaborative Use at Elon University” Moore, Train, Miyamoto, Uno, Institutional Development Grant, North Carolina Biotechnology Center, 2012, $35,156
  • “Developing Fluorescent Microscopy Labs for Cell Biology and Genetics” Miyamoto, Uno, Train, Niedziela, and Chandrasekeran, Center for Advancement of Teaching and Learning Grant, Elon University 2012, $4,179
  • American Society for Cell Biology Faculty Travel Award 2012, $350
  • Undergraduate Research Program Faculty Travel Grant 2012, $250
  • “Purchase of EVOS Fluorescent microscope for teaching and research”, Miyamoto, Uno, Train and Niedziela, Deans’ Office 2012, $25,000
  • Undergraduate Faculty and Undergraduate Travel Award American Association of Immunologists 2012, $1,500 (faculty) and $1,000 (student-Morgan Gregg)
  • "Acquisition of Fluorescent Detection Equipment for Interdisciplinary and Collaborative Use at Elon University”, Institutional Development Grant, North Carolina Biotechnology Center, submitted but not funded, Aug 2011, Moore, Miyamoto, Train, Matera, Uno, Vick, $74,000
  • “Aquatic Habitat to Establish Zebrafish Animal Model,” Associate Provost Special Grant, Elon University, May 2011, Niedziela, Miyamoto, Uno, $20,336
  • “Acquisition of a Tip Sonicator for Research and Teaching” Fund for Excellence in the Arts and Sciences, Elon University, 2011, Moore, Triffo, Miyamoto, $2,995
  • “Exploring Interdisciplinary Opportunities in Computational Science”, Fund for Excellence in the Arts and Sciences, Elon University, 2010, Collaborator, $1,850
  • “Biology Majors Alumni Panel-Life after Elon: insights about transition into multiple career paths”

Departmental Mini-Grants for Student Transitions/Life after Elon Programs

Elon University, Izzo and Miyamoto, 2010, $340

  •  “Improvement of Biotechnology Resources for Biology Research and Teaching of Undergraduate Students at Elon University”, Institutional Development Grant, North Carolina Biotechnology Center, 2008, Co-Investigator
  • “Acquisition of a Laser Scanning Confocal Microscope for Research and Training in Biology and Physics at Wake Forest University”, Major Research Instrumentation Award, National Science Foundation, August 2007-2009, Collaborator
  • Faculty Research & Development Grant, Elon University, 2009
  • Faculty Research & Development Grant, Elon University, 2007
  • Faculty Research & Development Grant, Elon University, 2006
  • Hulquist Award, Elon University, 2005
  • National Institutes of Health Ruth L. Kirschstein National Research Service Award, 2003-2005
  • R.W. Butcher Achievement Award, University of Texas at Houston Graduate School of Biomedical Sciences, 2004
  • National Institutes of Health Immunology Training Grant, 2000-2001
  • National Institutes of Health Travel Grant Award, Keystone Symposia, 2000

Publications

P. Vanderslice, D.G Woodside, A.R. Caivano, E.R. Decker, C.L. Munsch, S.J. Sherwood, W.S. LeJeune, Y.J. Miyamoto, B.W. McIntyre, R.G. Tilton, and A.F.D. Dixon. 2010. Potent in vivo suppression of inflammation by selectively targeting the high affinity conformation of integrin α4β1. Biochemical and Biophysical Research Communications. 400(4): 619-624.

 

L.K. Nutt, M.R. Buchakjian, E. Gan, R. Darbandi, S.Y. Yoon, J.Q. Wu, Y.J. Miyamoto, J.A. Gibbon, J.L. Andersen, C.D. Freel, W. Tang, C. He, M. Kurokawa, Y. Wang, S.S. Margolis, R.A. Fissore, S.S. Kornbluth. 2009. Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.  Dev Cell. Jun;16(6):856-66.

 

R.L. Juliano, V.R. Dixit, H. Kang, Y.K. Kim, Y. Miyamoto, and D. Xu.  2005.  Epigenetic manipulation of gene expression:  a toolkit for cell biologists.  Journal of Cell Biology. 169:847-857.

 

H. Kang, M.H.  Fisher, D. Xu, Y.J. Miyamoto, A. Marchand, A. Van Aerschot, P. Herdewijn, R.L. Juliano.  2004.  Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides. Nucleic Acids Res.  32:4411-9.

 

Y.J. Miyamoto, P.J. Reddig, and R.L. Juliano. 2004. Regulation of signal transduction by integrins.  Handbook of Experimental Pharmacology (Eds J. Behrens and J Nelson) Springer, Heidleberg.

 

Y.J. Miyamoto, J.S. Mitchell, and B.W. McIntyre.  2003.  Physical association and functional interaction between β1 integrin and CD98 on human T lymphocytes.  Molecular Immunology.  39:739-751.

 

Y.J. Miyamoto, B.F. Andruss, J.S. Mitchell, M.J. Billard, and B.W. McIntyre.  2003.  The dynamic effects of integrin coactivation and signaling in T lymphocytes.  Immunologic Research. 27:71-84.

 

D.G. Woodside, D.K. Wooten, T.K. Teague, Y.J. Miyamoto, E. Krohn, T. Udagawa, and B.W. McIntyre.  2003.  Control of T lymphocyte morphology by the GTPase Rho.  BMC Cell Biology. 4:2.

 

L. Lee, Y.J. Miyamoto, B.W. McIntyre, M. Hook, K. McCrea and E.L. Brown.  2002.  Prevention of T cell-mediated responses by the Major Histocompatibility Complex Class II analog protein from Staphylococcus aureus.  Journal of Clinical Investigation.  110: 1461-1471.

 

Y.J. Miyamoto, E.R. Wann, T. Fowler, E. Duffield, M. Höök, and B.W. McIntyre.  2000.  The

fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus can mediate human T lymphocyte adhesion and coactivation.  Journal of Immunology.  166:5129-5138.

 

A.P. Warren, K. Patel, Y. Miyamoto, J.N. Wygant, D.G. Woodside, and B.W. McIntyre.  2000.  Convergence between CD98 and β1 integrin mediated T lymphocyte costimulation.  Immunology, 99:62-68.

 

Presentations

“Research in Academia” Invited speaker to BIO205 Introduction to Biological Research, Campbell University, October 9, 2013

 

“Examining the Role of mTOR in T cell Proliferation and Migration Under Immunosuppression by Rapamycin”

Morgan J. Gregg1, Matthew J. Billard2, Teresa K. Tarrant2, Yuko J. Miyamoto1

1Elon University, Department of Biology, 2Thurston Arthritis Research Center, UNC Chapel Hill Department of Medicine, American Society for Cell Biology, San Francisco, CA, December 15-19, 2012

 

“Elon's Biology Cabinet: An IT/Faculty Partnership in Online Resource Development.” 2011 EDUCAUSE Southeast Regional Conference, Charlotte, NC, June 1-3, 2011

 

“The Online Biology Cabinet: A New Model for Faculty Creation of Video Resources in Science Lab Instruction”

2011 Lilly Conference on College & University Teaching, Greensboro, NC, February 4-6, 2011

 

“The Effects of Targeting Cytoskeletal Proteins with siRNA”

104th Annual Meeting of the North Carolina Academy of Science

East Carolina University, Greenville, NC, March 30-April 1, 2007

 

“Manipulating Focal Contact Proteins with Small Interfering RNA (siRNA)”

Tri-Beta Induction Ceremony

Elon University, Elon, NC, March 29, 2006

Professional Activities

2001-present      American Society for Cell Biology

2005-present      North Carolina Academy of Sciences

2009-present      Council on Undergraduate Research Member

2012                 American Association of Immunologists

2005-2007          Association of Southern Biologists

Service Activities

2006-current      Mentor for Duke Preparing Future Faculty Program

2006-current      Faculty Advisor Biology Club/Tri-Beta Biology Honor Society

2010-current      Biochemistry Program Advisory Committee Member

2008-current      Health Professions Advisory Committee Member

2013-2015          Lumen Advisory Committee Member

2013-2016          Alternate member of Elon University Institutional Animal Care and Use Committee (IACUC)

2009-2013          Undergraduate Research Program Committee Member

2010-2013          Public Health Advisory Committee Member

2013, 2014         Public Health Search Committee Member

2012                 Ad Hoc Committee Member on Internships in the College of Arts and Science

2012                   Interviewer for a candidate for the Physics/Engineering search

2011                 Task Force on Faculty Release Time Committee Member

2011, 2013         PURM Journal Article Reviewer

2008-2010          Honors Advisory Committee Member

2010                 Mediator for “I cannot believe someone just said that:” Creating Courageous Conversations in Our Classes and on Campus