Andrew Fischer

Biochemistry / Psychology / Math
Stevensville, Md.
Project title: Mechanism of neurotoxic α-synuclein oxidation by dopamine in Parkinson’s disease
Mentor: Kathryn Matera

Spring 2014

The first thing I accomplished this semester was repeating an experiment I had done in the fall. It was a thioflavin T assay that allowed me to quantify the degree to which norepinephrine inhibited the formation of large protein aggregates. I repeated the experiment because, now that I have the procedure worked out, I wanted to add error bars representing statistical significance to the graph of the data. Next, I spent a majority of the semester running western blot experiments with norepinephrine primary antibodies on oligomer aggregates. This was done to try to figure out how norepinephrine was interacting with the protein to inhibit large fibril formation and accelerate smaller oligomer formation. Since norepinephrine is not a protein, it was difficult to get this procedure to work, and unfortunately I was unable to work out the kinks before the end of the semester. My work was presented orally at NCUR in Lexington, KY and on SURF day. Finally, I spent the last part of the semester taking everything I have accomplished since summer 2012 and putting into a written form.

For More Information

Dr. Ann J. Cahill
Professor of Philosophy
Spence Pavilion 111
2340 Campus Box
Elon, NC 27244
Phone: (336) 278-5703


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