The associate professor of mathematics and Jaclyn (DeVincent) Ashcraft '16 worked with Nicholas Luke from North Carolina A&T State University on the article, which appears in Volume 8 of the journal BIOMATH.
Associate Professor of Mathematics Karen Yokley and Jaclyn (DeVincent) Ashcraft ’16 recently published an article that explores how structural differences affect mathematical model output.
The paper, “A computational investigation of the ventilation structure and maximum rate of metabolism for a physiologically based pharmacokinetic (PBPK) model of inhaled xylene,” discusses how different values for the maximum rate of xylene metabolism can result in similar compartmental predictions when used with different equations describing inhalation. Differences in ventilation equation structure may affect parameter estimates found through inverse problems, although further investigation is needed with more complicated models.
The article was co-authored by Nicholas Luke from North Carolina A&T State University and appears in Volume 8 of the journal BIOMATH.