Ryu, assistant professor of mathematics, published a paper on investigating the impact of combination therapy of antibiotic and phage on the immune system.
Assistant Professor of Mathematics Hwayeon Ryu has published a peer-reviewed paper entitled “Investigating the impact of combination phage and antibiotic therapy: a modeling study” in Association for Women in Mathematics (AWM)-Springer Series.
This work is a result of recent collaboration from the UCLA Institute for Pure & Applied Mathematic (IPAM) workshop in 2019 with mathematical biologists including Mary Ann Horn at Case Western Reserve University and Rebecca Segal at Virginia Commonwealth University. In this collaboration, Ryu and co-authors studied combination therapy of antibiotic and phage, including the effect of the immune system based on mathematical modeling. These results received attention from Dwayne Roach at San Diego State University, an experimental biologist working on the effect of innate immune response to phages. This naturally led to a new collaboration project, in which we will investigate the bacteria-phage interaction both without immune response and with it using mathematical modeling and experimental data (provided by Roach’s lab).
Focusing on the groundbreaking work of women in mathematics past, present, and future, Springer’s AWM Series presents the latest research or proceedings of conferences worldwide organized by AWM. All works are peer-reviewed to meet the highest standards of scientific literature, while presenting topics at the cutting edge of pure and applied mathematics, as well as in the areas of mathematical education and history.
S. Bañuelos, H. Gulbudak, M.A. Horn, Q. Huang, A. Nandi, H. Ryu, and R. Segal. Investigating the impact of combination phage and antibiotic therapy: a modeling study, In Using Mathematics to Understand Biological Complexity: From Cells to Populations, vol. 22, 111-134, Association for Women in Mathematics-Spring Series, R. Segal, B. Shtylla, and S. Sindi (eds.), 2021. (all authors with equal contribution).