Hwayeon Ryu, associate professor of mathematics, published a paper in Mathematical Biosciences on investigating bistable dynamics arising from macrophage–tumor interactions in the tumor microenvironment.
Associate of Mathematics Hwayeon Ryu has published a peer-reviewed paper entitled “Modeling bistable dynamics arising from macrophage–tumor interactions in the tumor microenvironment” in “Mathematical Biosciences,” one of top-tier journals in the field of mathematical biology.
This work was from international collaboration with three other mathematical biologists including Susanna Röblitz at the University of Bergen in Norway, partially funded by American Institute of Mathematics through its Structured Quartet Research Ensembles program and Elon University Faculty Research & Development Full-Year, Full-Pay Sabbatical Award with Financial Assistance. In this collaboration, Ryu (serving as the first as well as corresponding author) and co-authors develop and analyze a mathematical model to describe the temporal evolution of the tumor volume alongside different phenotypes of tumor-associated macrophages (TAMs), which extends their previous work on a single-cell model in the absence of tumors. Our new population-level modeling approach allows for investigating the impact of TAMs on tumor growth and tumors’ control of TAM phenotypes. To that end, model results are linked to treatment strategies that manipulate the bistable system to transition from high to low tumor volume.
Mathematical Biosciences, established in 1967, is one of highly cited, top-tier journals in the field of mathematical biology. It is a monthly peer-reviewed scientific journal covering work that provides new concepts or new understanding of biological systems using mathematical models, or methodological articles likely to find application to multiple biological systems.